Ensuring the sustainable production of potato is an important challenge facing agriculture globally. Insect pests are major biotic constraints affecting potato yields and tuber quality. The high pesticide uses to control them is of high human and environmental health concern, and it is expected that this will be further exacerbated through impacts of climate change. The chapter provides an overview of the geographical distribution of potato insect pests and their importance in tropical, subtropical, and temperate potato production regions. Climate change will potentially contribute to expand their geographical range of distribution, and increasing populations will lead to greater crop and post-harvest losses. Good progress has been made in applying insect pest modeling in pest risk analysis of potato pests to inform and create better awareness of future pest risks under climate change. Potato pests include some of the species which have evolved resistance to a wide variety of chemicals; and potato growers have already experienced the situation that available chemicals failed to control their targets. This chapter emphasizes the development, use, and adaptation of Integrated Pest Management (IPM) across all potato-growing regions of the world. Ultimately, this will lead to sustainable and more resilient potato production systems not overly dependent on pesticides. IPM requires a good knowledge and understanding of individual potato production systems; identifying pest species, knowing their biology and symptoms of infestation is essential for making educated decisions on their integrated management. To address this need, the chapter provides detailed information for a total of 49 insect pests of potato and the status quo of their management around the world.