Currently there is no effective mechanism for measuring the potential benefits of integrated pest and disease interventions in terms of reducing pesticide risks in potato production in developing countries. The environmental impact quotient (EIQ), a composite hazard indicator, was applied to data from potato field trials implemented in Ecuador to evaluate the practical boundaries of this metric related to potato production practices in the Andes. The EIQ was also applied to data from two independent farmer surveys, one from Peru and one from Ecuador to compare potato farming practices and the utility of the EIQ when applied to existing survey data. In the Ecuadorian field trials, the EIQ values, i.e., environmental impact (EI) per ha, varied greatly among the different potato systems tested and ranged from 40 for an integrated pest management system (resistant cultivar plus less hazardous pesticides) to 1235 for a high-input conventional system (susceptible cultivar plus frequent use of hazardous pesticides). Thus, this parameter demonstrates substantial variation under different conditions and different crop management approaches. EI per ha values from the two surveys fell within the range found in the field trial, but in the survey values were toward the lower end, ranging from 64 to 213. Methodical and biophysical factors are discussed that may account for the relatively low EI per ha found in the field survey data. Our study demonstrates the utility of the EIQ for assessing health and environmental hazards of potato production in the Andes and potentially other areas in the developing world. Nonetheless, there are limitations to the EIQ as presently used and care is needed in the interpretation of results. We see our work as an initial step in the development of an integrated metric to estimate environmental and human health hazards related to pesticide use in potato production in the diverse conditions of developing countries.